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Inhibition of Glycolysis

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Under physiological conditions healthy cells get their energy in form of ATP from mitochondrial oxidative phosphorylation. In most tumor cells however an increased glycolysis of D-glucose for energy production known as Warburg effect is observed. The glycolytic phenotype of human endometrial, ovarian and breast cancer cells can be targeted for therapeutic intervention.
A therapy using both, specific inhibition of glycolysis and GnRH receptor-targeted therapy seems to be suitable for an effective strategy for treatment of above all inoperable, chemotherapy-resistant or recurring endometrial, ovarian and breast cancers and should be further evaluated.

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Funding:

  • Deutsche Krebshilfe - Dr. Mildred Scheel Stiftung, approved on August 9th 2013 for 3 years.

Publications:





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