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GnRH Receptor Target Therapy

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The GnRH receptor can be utilized for targeted therapies such as 

GnRH receptor-mediated chemotherapy using cytotoxic GnRH analogs

- Hormone therapy using GnRH-I and GnRH-II analogs

- GnRH receptor-mediated gene therapy

The majority of human ovarian, endometrial and breast cancers express GnRH receptors. Apart from reproductive organs (ovary, fallopian tube, uterus) that are normally removed during surgical therapy of ovarian or endometrial cancer, other organs and hematopoetic stem cells do not express GnRH receptors. In addition, a tumor specific signal transduction exists in tumor cells, which is basically different of classical GnRH receptor signal transduction, known to operate in pituitary gonadotrophs.

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1.) GnRH receptor targeted chemotherapy

Funding:

  • Basic Research: Deutsche Krebshilfe - Dr. Mildred Scheel Stiftung (10-1299)

  • Clinicial Trials: Aeterna Zentaris Inc.

Publications:

Commentary:

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2.) hormone therapy using GnRH-I and GnRH-II analogs

Funding:

  • Deutsche Krebshilfe - Dr. Mildred Scheel Stiftung, approved on 08/18/2004 for 2 years

  • Deutsche Krebshilfe - Dr. Mildred Scheel Stiftung, approved on 01/22/2007 for 2 years

  • Deutsche Krebshilfe - Dr. Mildred Scheel Stiftung, approved on 07/24/2009 for 2 years

Publications:

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3.) GnRH receptor-mediated gene therapy

Funding:

  • School of Medicine, Georg-August-University of Göttingen, 2000

Publication:

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