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AG Wegwitz |
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PD Dr. rer. nat. Florian Wegwitz
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Publikationen: |
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Prokakis E, Bamahmoud H, Jansari S, Fritsche L, Dietz A, Boshnakovska A, Rehling P, Johnsen SA, Gallwas J, Wegwitz F. USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration. Cell Commun Signal. 2024 Feb 12;22(1):120. Prokakis
E, Jansari S, Boshnakovska A, Wiese M, Kusch K, Kramm C, Dullin C,
Rehling P, Glatzel M, Pantel K, Wikman H, Johnsen SA, Gallwas J,
Wegwitz F. RNF40 epigenetically modulates glycolysis to support the
aggressiveness of basal-like breast cancer. Cell Death Dis. 2023 Sep
28;14(9):641. Wang
X, Kutschat AP, Aggrey-Fynn J, Hamdan FH, Graham RP, Wixom AQ, Souto Y,
Ladigan-Badura S, Yonkus JA, Abdelrahman AM, Alva-Ruiz R, Gaedcke J,
Ströbel P, Kosinsky RL, Wegwitz F, Hermann P, Truty MJ, Siveke JT, Hahn
SA, Hessmann E, Johnsen SA, Najafova Z. Identification of a
ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer
Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma. Mol
Cancer Res. 2023 Sep 1;21(9):881-891. Pantelaiou-Prokaki G, Reinhardt O, Georges NS, Agorku DJ, Hardt O, Prokakis E, Mieczkowska IK, Deppert W, Wegwitz F, Alves F. Basal-like mammary carcinomas stimulate cancer stem cell properties through AXL-signaling to induce chemotherapy resistance. Int J Cancer. 2023 ;152(9):1916-1932. Werner
M, Dyas A, Parfentev I, Schmidt GE, Mieczkowska IK, Müller-Kirschbaum
LC, Müller C, Kalkhof S, Reinhardt O, Urlaub H, Alves F, Gallwas J,
Prokakis E, Wegwitz F. ROBO3s: a novel ROBO3 short isoform promoting
breast cancer aggressiveness. Cell Death Dis. 2022 Sep 3;13(9):762. Krebs N, Klein L, Wegwitz F,
Espinet E, Maurer HC, Tu M, Penz F, Küffer S, Xu X, Bohnenberger H,
Cameron S, Brunner M, Neesse A, Kishore U, Hessmann E, Trumpp A,
Ströbel P, Brekken RA, Ellenrieder V, Singh SK. Axon guidance receptor
ROBO3 modulates subtype identity and prognosis via AXL-associated
inflammatory network in pancreatic cancer. JCI Insight. 2022 Aug
22;7(16):e154475. Hoen L, Rudisch C, Wick M, Indenbirken D, Grundhoff A, Wegwitz F, Kalkhof S, Hildebrand J. Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes. Cells. 2022 Mar 11;11(6):959. Pantelaiou-Prokaki G, Mieczkowska I, Schmidt GE, Fritzsche S, Prokakis E, Gallwas J, Wegwitz F. HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer. Clin Epigenetics. 2022 Jan 11;14(1):7. Tu M, Klein L, Espinet E, Georgomanolis T, Wegwitz F,
Li X, Urbach L, Danieli-Mackay A, Küffer S, Bojarczuk K, Mizi A,
Günesdogan U, Chapuy B, Gu Z, Neesse A, Kishore U, Ströbel P, Hessmann
E, Hahn SA, Trumpp A, Papantonis A, Ellenrieder V, Singh SK.
TNF-α-producing macrophages determine subtype identity and prognosis
via AP1 enhancer reprogramming in pancreatic cancer. Nat Cancer. 2021
Nov;2(11):1185-1203. Mieczkowska IK, Pantelaiou-Prokaki G, Prokakis E, Schmidt GE, Müller-Kirschbaum LC, Werner M, Sen M, Velychko T, Jannasch K, Dullin C, Napp J, Pantel K, Wikman H, Wiese M, Kramm CM, Alves F, Wegwitz F. Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments. Cell Death Dis . 2021 Nov 29;12(12):1118. Isermann T, Şener ÖÇ, Stender A, Klemke L, Winkler N, Neesse A, Li J, Wegwitz F, Moll UM, Schulz-Heddergott R. Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity. Nat Commun. 2021 Jun 29;12(1):4019. Kosinsky RL, Zerche M, Kutschat AP, Nair A, Ye Z, Saul D, von Heesen M, Friton JJ, Schwarzer AC, Paglilla N, Sheikh SZ, Wegwitz F, Sun Z, Ghadimi M, Newberry RD, Sartor RB, Faubion WA, Johnsen SA. RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease. Cell Death Differ. 2021 Nov;28(11):3161-3175. Prokakis E, Dyas A, Grün R, Fritzsche S, Bedi U, Kazerouni ZB, Kosinsky RL, Johnsen SA, Wegwitz F.
USP22 promotes HER2-driven mammary carcinoma aggressiveness by
suppressing the unfolded protein response. Oncogene. 2021 Jun;40(23):4004-4018 Najafova Z, Liu P, Wegwitz F, Ahmad M, Tamon L, Kosinsky RL, Xie W, Johnsen SA,
Tuckermann J. RNF40 exerts stage-dependent functions in differentiating osteoblasts
and is essential for bone cell crosstalk. Cell Death Differ. 2021 Feb;28(2):700-714 Kolb K, Hellinger J, Kansy M, Wegwitz F, Bauerschmitz G, Emons G,
Gründker C. Influence of ARHGAP29 on the Invasion of Mesenchymal-Transformed
Breast Cancer Cells. Cells.
2020 Dec 5;9(12):2616 Wegwitz F, Prokakis E, Pejkovska A, Kosinsky RL,
Glatzel M, Pantel K, Wikman H, Johnsen SA. The histone H2B ubiquitin ligase RNF40 is
required for HER2-driven mammary tumorigenesis. Cell Death Dis. 2020 Oct
17;11(10):873 Wüst HM, Wegener A, Fröb F, Hartwig AC, Wegwitz F, Kari V, Schimmel M, Tamm ER,
Johnsen SA, Wegner M, Sock E. Egr2-guided histone H2B monoubiquitination is required
for peripheral nervous system myelination. Nucleic Acids Res. 2020 Sep 18;48(16):8959-8976 Kosinsky RL, Helms M, Zerche M, Wohn L, Dyas A,
Prokakis E, Kazerouni ZB, Bedi U, Wegwitz
F, Johnsen SA. USP22-dependent HSP90AB1 expression promotes resistance to
HSP90 inhibition in mammary and colorectal cancer. Cell Death Dis. 2019 Dec
4;10(12):911 Kosinsky RL, Zerche M, Saul D,
Wang X, Wohn L, Wegwitz F,
Begus-Nahrmann Y, Johnsen SA. USP22
exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR
activity. Cell Death Differ. 2020 Apr;27(4):1328-1340 Schneider D, Chua RL, Molitor N,
Hamdan FH, Rettenmeier EM, Prokakis E, Mishra VK, Kari V, Wegwitz F, Johnsen SA, Kosinsky RL. The E3 ubiquitin ligase RNF40
suppresses apoptosis in colorectal cancer cells. Clin Epigenetics. 2019 Jul 2;11(1):98 Sen M, Wang X, Hamdan FH, Rapp J, Eggert J,
Kosinsky RL, Wegwitz F, Kutschat AP,
Younesi FS, Gaedcke J, Grade M, Hessmann E, Papantonis A, Strӧbel P, Johnsen SA. ARID1A
facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent
manner in colorectal cancer cells. Clin Epigenetics. 2019 Jun 19;11(1):92 Kari V, Raul SK, Henck JM, Kitz J, Kramer F,
Kosinsky RL, Übelmesser N, Mansour WY, Eggert J, Spitzner M, Najafova Z,
Bastians H, Grade M, Gaedcke J, Wegwitz
F, Johnsen SA. The histone methyltransferase DOT1L is required for proper
DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Clin Epigenetics. 2019 Jan 7;11(1):4 Puig B, Altmeppen HC, Linsenmeier L, Chakroun
K, Wegwitz F, Piontek UK, Tatzelt J,
Bate C, Magnus T, Glatzel M. GPI-anchor signal sequence influences PrPC
sorting, shedding and signalling, and impacts on different pathomechanistic aspects
of prion disease in mice. PLoS Pathog. 2019 Jan 4;15(1):e1007520 Kosinsky RL, Chua RL, Qui M, Saul D, Mehlich D,
Ströbel P, Schildhaus HU, Wegwitz F,
Faubion WA, Johnsen SA. Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and
Reduces Colitis Burden in Mice. J Crohns Colitis. 2019 Mar 26;13(3):362-373 Mishra VK, Wegwitz
F, Kosinsky RL, Sen M, Baumgartner R, Wulff T, Siveke JT, Schildhaus HU,
Najafova Z, Kari V, Kohlhof H, Hessmann E, Johnsen SA. Histone deacetylase
class-I inhibition promotes epithelial gene expression in pancreatic cancer
cells in a BRD4- and MYC-dependent manner. Nucleic Acids Res. 2017 Jun
20;45(11):6334-6349 Mishra VK, Subramaniam M, Kari V, Pitel KS,
Baumgart SJ, Naylor RM, Nagarajan S, Wegwitz
F, Ellenrieder V, Hawse JR, Johnsen SA. Krüppel-like Transcription Factor
KLF10 Suppresses TGFβ-Induced
Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism. Cancer
Res. 2017 May 1;77(9):2387-2400 Xie W, Nagarajan S, Baumgart SJ, Kosinsky RL,
Najafova Z, Kari V, Hennion M, Indenbirken D, Bonn S, Grundhoff A, Wegwitz F, Mansouri A, Johnsen SA. RNF40
regulates gene expression in an epigenetic context-dependent manner. Genome Biol.
2017 Feb 16;18(1):32 Nagarajan S, Bedi U, Budida A, Hamdan FH,
Mishra VK, Najafova Z, Xie W, Alawi M, Indenbirken D, Knapp S, Chiang CM,
Grundhoff A, Kari V, Scheel CH, Wegwitz
F, Johnsen SA. BRD4 promotes p63 and GRHL3 expression downstream of FOXO in
mammary epithelial cells. Nucleic Acids Res. 2017 Apr 7;45(6):3130-3145 Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J,
Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W,
Horst AK. CEACAM1 controls the
EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget. 2016
Sep 27;7(39):63730-63746 Hossan T, Nagarajan S, Baumgart SJ, Xie W,
Magallanes RT, Hernandez C, Chiaroni PM, Indenbirken D, Spitzner M,
Thomas-Chollier M, Grade M, Thieffry D, Grundhoff A, Wegwitz F, Johnsen SA. Histone Chaperone SSRP1 is Essential for Wnt
Signaling Pathway Activity During Osteoblast Differentiation. Stem Cells. 2016
May;34(5):1369-76 Falker C, Hartmann A, Guett I, Dohler F,
Altmeppen H, Betzel C, Schubert R, Thurm D, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M. Exosomal cellular
prion protein drives fibrillization of amyloid beta and counteracts amyloid
beta-mediated neurotoxicity. J Neurochem. 2016 Apr;137(1):88-100 Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann
Y, Johnsen SA. Usp22 deficiency impairs intestinal epithelial lineage
specification in vivo. Oncotarget. 2015 Nov 10;6(35):37906-18 Maenz C, Lenfert E, Pantel K, Schumacher U,
Deppert W, Wegwitz F. Epithelial-mesenchymal
plasticity is a decisive feature for the metastatic outgrowth of disseminated
WAP-T mouse mammary carcinoma cells. BMC Cancer. 2015 Mar 26;15:178. doi:
10.1186/s12885-015-1165-5 Schreiber S, Gocht A, Wegwitz F, Deppert W, Schumacher U. Lectin histochemistry of murine
WAP-T mammary cancer reveals similar glycoconjugate changes to those in human
breast cancer. Anticancer Res. 2014 Dec;34(12):7045-53 Jannasch K, Wegwitz F, Lenfert E, Maenz C, Deppert W, Alves F. Chemotherapy of
WAP-T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell
dissemination. Int J Cancer. 2015 Jul 1;137(1):25-36 Lenfert E, Maenz C, Heinlein C, Jannasch K,
Schumacher U, Pantel K, Tolstonog GV, Deppert W, Wegwitz F. Mutant p53 promotes epithelial-mesenchymal plasticity
and enhances metastasis in mammary carcinomas of WAP-T mice. Int J Cancer.
2015 Mar 15;136(6):E521-33 Quante T, Wegwitz
F, Abe J, Rossi A, Deppert W, Bohn W. Aberrant Proliferation of
Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of
SV40-TAg Transgenic Mice. Front
Oncol. 2014 Jun 26;4:168 Otto B, Streichert T, Wegwitz F, Gevensleben H, Klätschke K,
Wagener C, Deppert W, Tolstonog GV. Transcription factors link mouse WAP-T mammary tumors with human breast
cancer. Int J Cancer. 2013 Mar 15;132(6):1311-22 Otto B, Gruner K, Heinlein C, Wegwitz F, Nollau P, Ylstra B, Pantel
K, Schumacher U, Baumbusch LO, Martin-Subero JI, Siebert R, Wagener C,
Streichert T, Deppert W, Tolstonog GV. Low-grade and high-grade mammary
carcinomas in WAP-T transgenic mice are independent entities distinguished by
Met expression. Int J Cancer. 2013 Mar 15;132(6):1300-10 Hirner H, Günes C, Bischof J, Wolff S, Grothey
A, Kühl M, Oswald F, Wegwitz F, Bösl
MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild
U. Impaired CK1 delta activity attenuates SV40-induced cellular transformation
in vitro and mouse mammary carcinogenesis in vivo. PLoS One. 2012;7(1):e29709 Gerstel D, Wegwitz F, Jannasch K, Ludewig P, Scheike K, Alves F, Beauchemin N,
Deppert W, Wagener C, Horst AK. CEACAM1
creates a pro-angiogenic tumor microenvironment that supports tumor vessel
maturation. Oncogene. 2011 Oct 13;30(41):4275-88 Wegwitz F, Kluth MA, Mänz C, Otto B, Gruner
K, Heinlein C, Kühl M, Warnecke G, Schumacher U, Deppert W, Tolstonog GV. Tumorigenic
WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic
cancer cell system. PLoS One. 2010 Aug 11;5(8):e12103 Jannasch K, Dullin C, Heinlein C, Krepulat F, Wegwitz F, Deppert W, Alves F. Detection of different tumor growth kinetics in single transgenic mice with oncogene-induced mammary carcinomas by flat-panel volume computed tomography. Int J Cancer. 2009 Jul 1;125(1):62-70 |
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